Antagonist Cafe

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2727 S 12th St
Saint Louis, MO 63118

Antagonist Cafe, nestled in the heart of Saint Louis, MO, offers a unique culinary experience for locals and visitors alike. Boasting a prime location just across from the renowned Anheuser-Busch Brewery Tour, this cafe provides a cozy ambiance to enjoy delicious treats.

From delectable pastries to aromatic coffees, Antagonist Cafe serves up a delightful array of menu items to satisfy any craving. Each visit promises a welcoming atmosphere where patrons can indulge in freshly brewed beverages and homemade delicacies.

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4.5

(38)

Photo of Mindy P.
Mindy P.
10/31/2025

What a great spot for coffee! If you are in the area, you have to check it out! I am limiting my caffeine intake so went for some tea, it tasted great and I feel like I got a lot of bang for...

Photo of Kimberly W.
Kimberly W.
10/16/2025

I heard about this place months ago, but didn't get a chance to actually check them out until recently. They are located in a former jail and incorporate this into the theme of the shop, so it's...

Photo of Carri N.
Carri N.
10/1/2025

Well repurposed old police station now cafe and board game businesses occupy this space. Got a Café au lait with a nice creamy foam on top. First time having one of those and it was pretty...

Photo of Abigail R.
Abigail R.
1/19/2026

Popped in for a little pick me up and had heard so many fun things about the Antagonist Cafe inside a former police station. Really nice exterior and repurposed jail cells that serve as a more...

Photo of Devon B.
Devon B.
12/28/2025

This place is awesome! Gluten free and gluten filled options for delicious treats are available! Great drinks! Plenty of cool places to sit! Very nice staff! HIGHLY recommend coming here - even...

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