Lytle Pharmacy

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340 S Main St
Rochester, MI 48307

Lytle Pharmacy, located in Rochester, MI, has been serving the community since 1890 and took over ownership of the historic Rochester Opera House building in 1987. Their full-service pharmacy offers delivery, free consultations, and a variety of products including greeting cards, gifts, groceries, toys, and seasonal items.

With a long-standing presence in the area, Lytle Pharmacy provides a convenient one-stop shop for pharmaceutical needs and a diverse selection of retail products, all housed within the charming setting of the Rochester Opera House building.

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Reviews

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3.521 reviews
Susan W.
12/15/2025

Efficient, friendly service at the Rx counter -- something that's very hard to find at the "big box" drug stores. Lytle's also has a charming gift shop, but they haven't forgotten what the real...

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Amanda L.
7/9/2024

I've lived in the Rochester area for nearly a decade now and this is my first time in to Lytle Pharmacy! I have frequented downtown Rochester OFTEN, but always find Lytle to be closed! So please...

Dee B.
4/23/2025

Always a great choice for hometown service Efficient and caring We always get our prescriptions here

Vijay S.
4/30/2025

They refused to fill my 3 month script claiming they were losing money on it, but were willing to fill a 1 month script. the facts: 1 month script insurance is paying them $206 3 month script...

Mel L.
10/1/2024

When my pharmacy closed I transferred to Lytle. Everyone is friendly and helpful. They always have my medication stocked and ready for pickup the same day. If you're looking for a new pharmacy I...

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